CD4 and type 2 diabetes mellitus: In type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered, as compared with that of the control group, and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than did the microalbuminuric patients.