Indeed, it is noteworthy that the alanine mutated in the TLDc domain of the TBC1D24 protein in human FIME is not only conserved in OXR1 (Figure S8B), but has also been shown to inhibit neurite outgrowth in vitro[16], suggesting that further study into this family of proteins will also be important for neurological disorders outside of those directly linked with oxidative stress [47]. Here, OXR1 is linked to nervous system disorder.