At this stage, sciatic nerves from Mtmr2−/−Fig4−/− double null mice were more severely hypomyelinated than Mtmr2+/+Fig4−/− mice with a higher g-ratio, demonstrating that Mtmr2 loss exacerbates the neuropathy of Mtmr2+/+Fig4−/− mice (Figure 5E). Here, FIG4 is linked to neuropathy.