Interestingly, polyclonal stimulation of CD8+ T cells with Staphylococcal Enterotoxin B (Figure S4C in Text S1), anti-CD3 and anti-CD28 antibodies (Figure S4D in Text S1) or PMA-Ionomycin (Figure S4E in Text S1) mounted lower responses in SLE patients compared to healthy controls. This evidence concerns the gene CD28 and systemic lupus erythematosus.