Surface exposed CD107a is inversely correlated with granzyme B release, and thus a marker of recent history of cytotoxic activity.[21] As shown, CD8+ T cells from SLE patients specific for lytic EBV antigens carry similar loads of granzyme B (Figure 3D – upper left panel), but are dramatically less able to degranulate (P = 0.0009, Figure 3B upper panel) and release their cytotoxic content (P = 0.0001, Figure 3D – upper right panel) following stimulation, compared to EBV-specific CD8+ T cells from healthy controls. This evidence concerns the gene LAMP1 and systemic lupus erythematosus.