It was reported in an early study that T cells from SLE patients are unable to control immunoglobulin production from EBV-exposed B cells.[19] Subsequently, Kang et al. observed that lupus patients had elevated frequencies of interferon-γ (IFN-γ) secreting EBV-specific CD4+ T cells, whereas no significant modification was observed for IFN-γ secreting EBV-specific CD8+ T cells.[12] Similarly, Berner et al. reported that the frequency of EBV-specific CD8+ T cells did not differ between SLE patients and healthy controls, when analysed using peptide-MHC tetramer probes. Here, CD4 is linked to systemic lupus erythematosus.