IFNG and hemophagocytic syndrome: Thus, NOG mice transplanted with EBV-HLH-derived PBMC are distinct from those transplanted with CAEBV-derived PBMC in the aggressive time course of the disease, internal hemorrhagic lesions, extremely high levels of IL-8 and IFN-γ in the peripheral blood, and the presence of EBV-infected B cells in lymphoid tissues.