This module also features relatively low copy number of several important genes in cancer such as NCOA3, a nuclear receptor co-activator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions, and CCND1 whose copy number gain and over-expression can alter cell cycle progression and may contribute to tumorigenesis, as well as MYBL2 which has been shown to activate the cell division cycle 2, cyclin D1. Here, NR0B1 is linked to cancer.