CCND1 and cancer: This module also features relatively low copy number of several important genes in cancer such as NCOA3, a nuclear receptor co-activator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions, and CCND1 whose copy number gain and over-expression can alter cell cycle progression and may contribute to tumorigenesis, as well as MYBL2 which has been shown to activate the cell division cycle 2, cyclin D1.