Interestingly, PSDF 7 is characterised by the under-expression of many functionally-related growth factors, such as GRB2 and FGFR2, as well as cancer-generic genes such as cyclin CCNB1, hypothesized tumour suppressor TP73 and mixed-lineage leukemia MLL. The enrichment map of PSDF 7 in Fig. 6(B) shows that its subtype-specific genes are enriched with many cancer pathways, among which the most significant are Chemokine signaling pathway and Endocytosis. Here, CCNB1 is linked to cancer.