This Utrn/Dmd interaction domain is missing in two of the NDE1 alleles that cause micro-lissencephaly [16],[17]; it is evolutionarily less conserved [14] and does not overlap with the recently identified Dynein interaction domain [28], as well as the previously defined Nde1 dimerization and LIS1 binding domains in the conserved N-terminal coiled-coil segment. This evidence concerns the gene PAFAH1B1 and lissencephaly spectrum disorders.