DAG1 and microcephaly: While discontinuous basal lamina was the major phenotype of inactivating dystroglycan after E14.5 by the GFAP-Cre mediated conditional mouse mutation [37], more recent analyses of mice with earlier and broader inactivation of Dag1 resulted in pelotropic defects including microcephaly, disorganized cortical layering, and neuronal overmigration [38].