To further explore the implications of this increased LRP1 expression on endocytosis of Angiopep-2 and ANG1005, we examined human U87 glioblastoma cells and found that the changes in mRNA and protein expression were associated with ∼100% increased uptake of Angiopep-2 (Figure 7A) and ANG1005 (Figure 7B). This evidence concerns the gene LRP1 and glioblastoma.