Prior studies showed that ANG1005 has a similar cytotoxic effect in vitro in U87 human glioblastoma cells as unconjugated paclitaxel (Regina et al, 2008), but those studies did not directly examine whether ANG1005 and Angiopep-2 entered cells by an LRP1-mediated mechanism. The gene discussed is LRP1; the disease is glioblastoma.