NFKB1 and Hodgkins lymphoma: Use of aspirin, a non-steroidal anti-inflammatory drug (NSAID), has been hypothesised to protect against HL (Chang et al, 2004) by inhibiting the pleiotropic transcription factor nuclear factor kappa-B (NF-κB) (Kopp and Ghosh, 1994), which is constitutively activated in malignant HL cells and required for their survival (Bargou et al, 1996).