CASP12 and amyotrophic lateral sclerosis: A total of 35 protein entities corresponding to 53 genes represented on the KEGG ALS pathway map (pseudogene CASP12 excluded) include membrane receptors, cytosolic or secreted proteins, kinases, phosphatases, proteases, and protein channels, which are likely to play a direct/indirect role in ALS pathogenesis to a variable degree at different stages that lead to motor neuron degeneration.