DCTN1 and amyotrophic lateral sclerosis: DYNLT1 (dynein, light chain, Tctex-type 1) encodes a component of the dynein-dynactin complex composed of dynactin (DCTN1), those mutations have been involved in ALS [26], while TARDBP encodes TAR DNA binding protein 43 (TDP-43), those mutations may cause ALS [27].