However, it is not significant to evaluate any correlation of the serum level of IL-6 or VEGF and −174G/C polymorphism in the proliferative stage of ED, because in this stage serum concentration does not influence the vitreous levels of IL-6 and VEGF, and the role of vitreous in retinal disorders is a matter of great interest. The gene discussed is IL6; the disease is retinal disorder.