NOS3 and open-angle glaucoma: Using women with multiparity who were homozygous for the common Gl298Asp NOS3 variant (GG) as the reference group, both homozygosity for the minor Glu298Asp variant (TT) among those with 3 or more children and homozygosity for the common variant (GG) among women with 1–2 children were adversely related to POAG (p=0.003; significant after multiple testing correction; Table 2).