SETD6 and head and neck carcinoma: We also validated the methylation of the ribosomal protein RPS27L by SETD6; RPS27L is overexpressed in multiple human cancers, including colon [28], prostate [29], breast [30], liver [31], and head and neck carcinomas [32], and was recently shown to be a p53 target gene that regulates p53 protein levels [33].