RENBP and Lassa fever: Due to our characterization of a prolonged IgM response in convalescent LF patients, high prevalence of IgM seropositive in healthy normal controls, and the failure of most IgM only suspected cases to display a dysregulated metabolic and inflammatory cytokine profile similar to LASV-specific Ag+ patients regardless of IgM status, we suggest that the traditional paradigm for diagnosis of acute LF in West Africa should be reconsidered and changed.