Consistent with this, many genes that were highly expressed in Type II vs. Type III infection of chicken fibroblasts and are known to be typically induced by NF-κB (e.g. CD83, HHIP, and CCL4) were found to map to chromosome X. Although we have not proven that this difference is in fact due to GRA15, this seems highly likely and suggests that for at least two major, polymorphic effectors, ROP16 and GRA15, and in at least the cell types so far examined, allele-dependent function is conserved in both mammals and avians, despite significant differences in the substrates with which they interact. This evidence concerns the gene HHIP and infection.