Our studies in TB patients revealed a series of immune and endocrine alterations characterized by increased levels of IFN-γ, IL-10, IL-6 and growth hormone, reduced amounts of testosterone and DHEA, in parallel to modest increases in the concentrations of cortisol, estradiol, prolactin, and thyroid hormones with no changes in insulin-like growth factor-1 [11]. The gene discussed is IL6; the disease is tuberculosis.