CD8A and cancer: Especially, CD8+ T lymphocytes, while their function is known to eliminate nascent transformed cells and contribute to immunosurveillance [31], it is reported that CD8+ tumor-infiltrating T cells are defective in effector phase function upon contact with tumor cells [32], and their infiltration is linked to unfavorable prognosis in certain types of cancer such as nonsmall cell lung cancer and nasopharyngeal carcinoma [33], [34].