Recent circumstantial evidence has further strengthened the idea that the IL-6/gp130/STAT-3 signaling axis serves as both an autocrine and paracrine amplification loop in lung adenocarcinoma, multiple myeloma, Ras-transformed cancer cells, and a colitis-associated cancer model [47], [48], [49], [50]. The gene discussed is STAT3; the disease is AL amyloidosis.