Among these genetic events, it is known that tumor suppressor promyelocytic leukemia (PML) protein expression is reduced or abolished in gastric cancer, and that this is associated with more extensive lymphatic invasion, higher pTNM staging, and unfavorable prognosis, suggesting that PML loss is linked to carcinogenesis and gastric carcinoma progression [2]. The gene discussed is PML; the disease is gastric carcinoma.