However, WHcAg-specific CD3+CD4− T cells from 2 of 4 animals showed a stronger degranulation in the presence of anti-wPD-L1 and WHc peptide at week 4 (2- fold) or week 6 (26- fold) post infection without an effect on proliferation, compared to WHcAg-derived peptide only (Fig. 6C), with no effect on proliferation of the cells. Here, CD4 is linked to infection.