Furthermore, our data suggested that future study on prognostication of severe influenza infection should consider the inclusion of cytokine/chemokine variables, because of their significant correlations with clinical progress and outcomes (e.g. a 10-fold increase in IL-6 is associated with >10 times higher risk for ICU admission)[8], [9], [15], [20], [21], [29], [31]. This evidence concerns the gene IL6 and influenza.