The PR gene, PGR, and 3 other genes (GATA3, STC2 and GLI3) [47], [48], [49] are increased in their expression, whereas the expression of 6 genes (AURKA, BUB1, CDC20, MKI67, HJURP, and CENPA) [50], [51], [52], [53], [54] is decreased in PR-positive breast tumors. The gene discussed is HJURP; the disease is breast neoplasm.