NF-κB inhibition in hepatocytes by expression of an IκB super-repressor (IκBαSR) transgene did not affect liver inflammation in Mdr2−/− mice but strongly reduced the development of hepatocellular carcinoma, suggesting that NF-κB activation promotes the survival of premalignant cells facilitating liver cancer development in this model [7]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.