Another 9 significant SNPs in our analysis were previously linked to bone phenotypes in candidate gene association studies, including rs4588 in GC, rs6256 in PTH, rs419598 in IL1RN, rs1801131 in MTHFR, rs1800896 in IL10, and rs1061624 in TNFRSF1B, rs1042358 in ALOX12, rs759330 in BGLAP, and rs2235579 in CLCN7. Four of these SNPs (rs759330, rs2235579, rs1800896 and rs1061624) were also associated with altered gene expression in the SCAN. This evidence concerns the gene MTHFR and spinocerebellar ataxia, autosomal recessive, with axonal neuropathy.