Interestingly, in field studies where efficacy against infection is the primary endpoint, CSP antibodies seemed to correlated with protection [7], [8], whereas no such correlation could be found with protection against clinical manifestation of disease [7], [9], except in a recent trial of RTS,S/AS02 in infants [10] and a recent analysis in children vaccinated with RTS,S/AS01 where anti-CSP antibody titers 6.5 months after vaccination seemed to correlate with protection [11]. This evidence concerns the gene DNAJC5 and infection.