In contrast, aging had major effects on USV of Tau.P301L mice where tauopathy not only exacerbated the modest age-related reduction of USV observed in FVB/N mice, dramatically reducing the quantitative USV parameters (Dur(USV), Nb(USV) and totT(USV) ), but also significantly altered the qualitative USV parameters (RangeFreq, use of low Freq(USV) components and complexity). Here, MAPT is linked to tauopathy.