MYC and acute lymphoblastic leukemia: Myc is a direct Notch target gene that contributes to leukemogenesis [39], [40], [41], and the failure of certain ICNs to induce T-ALL or maintain T-ALL cell growth might therefore stem from differing abilities to transactivate Myc. This idea was tested using the 8946 T-ALL cell line, which was derived from a murine T-ALL induced with a “doxycycline-off” human MYC transgene.