Myc provides important leukemogenic signals, as ectopic Myc expression rescues growth and survival of some, but not all, Notch-dependent human T-ALL cell lines when Notch signaling is inhibited [45], and conditional deletion of Myc impedes Notch1-dependent T-ALL development in mouse models [46]. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.