Feline leukemia viruses that transduce the coding sequences for the RAM and ANK domains of ICN2 accelerate T-ALL development [20], and transgenic LCK-ICN3 mice develop T-ALL with high penetrance and short latency periods [21], indicating that Notch2 and Notch3 also have leukemic potential. The gene discussed is NOTCH3; the disease is acute lymphoblastic leukemia.