BUB1B and metastatic malignant neoplasm in the lymph nodes: Many immunohistochemistry investigations have shown that overexpression of BUBR1, the protein of BUB1B, significantly correlates with higher histological grade, advanced pathological stage, and high cell proliferation in different types of tumors, e.g. with tumor recurrence and disease progression in bladder cancer [44]; with deep invasion, lymph node metastasis, liver metastasis, and poor prognosis in gastric cancer [48]; and with advanced stage, serous histology and high grade in ovarian cancer [49].