These genes have previously been associated with cancer though not glioma; BUB1 mutation was associated with lymph node metastasis and shorter relapse-free survival after surgery in colorectal cancers [54], TTK had an increased expression level in anaplastic thyroid carcinoma [55], and TTK expression correlated with tumor node metastasis (TNM) stage in gastric cancer [56]. Here, BUB1 is linked to central nervous system cancer.