These particular ways of TREK-1 modulation together with the generation of knock-out mice for TREK-1 (TREK-1−/−) has allowed the demonstration that TREK-1 channels play a key role in the cellular mechanisms of anaesthesia 18, neuroprotection [19], [27], pain [8], [9] and depression [25], [28]. Here, KCNK2 is linked to depressive disorder.