VDAC1 and hepatocellular carcinoma: Indeed, in HepG2 human hepatoma cells, MT polymerization/depolymerization by paclitaxel or colchicine is coupled with changes in inner mitochondrial membrane potential [20] that could be explained by the modulation of VDAC permeability to ATP/ADP and other mitochondrial respiratory substrates by the changing pool of dimeric tubulin in the cytosol.