PITX2 and congenital glaucoma: Nine different human genes have been associated with ASD or congenital glaucoma including FOXC1, PITX2, PITX3, FOXE3, PAX6, MAF, CYP1B1 and LMX1B. Mutations in the FOXC1 gene [7], or dosage effects due to deletions [8] or duplications [9], [10] in the 6p25 region that surrounds FOXC1 can all cause iridogoniodysgenesis; as can mutations in the PITX2/RIEG1 gene [11].