IFNA1 and chronic hepatitis C virus infection: Interferon-α (IFN-α) has been shown to have beneficial effects in patients with chronic hepatitis C. IFN-α, especially pegylated IFN-α therapy, leads to a rapid decline in HCV RNA levels in serum, and long-term responses to therapy are marked by the sustained reduction of HCV RNA in the serum and liver, leading to resolution of chronic Infection [3], [4].