In the newborns, the fasting glucose and insulin levels of IUGR pups were both lower than those of normal ones (4.17±0.41 mmol/l vs 4.36±0.41 mmol/l; 0.20±0.02 ng/ml vs 0.25±0.07 ng/ml), whereas glucose levels at 120 and 180 min after glucose load were significantly higher in IUGR group (P<0.05) (Fig. 3). The gene discussed is INS; the disease is fetal growth restriction.