In order to determine the internal relationship between IUGR and islet function and insulin sensitivity in detail, we established the IUGR rat model by maternal nutrition restriction during mid- to late-gestation, and selected male offsprings at different stages (newborn, 3 weeks, 7 weeks, 10 weeks, 15 weeks) in IUGR and normal groups as research objects. This evidence concerns the gene INS and fetal growth restriction.