VHL and neoplasm: When specific VHL haplotypes were evaluated individually and compared to the common 9-SNP referent haplotype T-A-A-A-G-G-A-C-A, two germline haplotypes were significantly associated with tumor-specific promoter hypermethylation, specifically T-A-C-G-A-T-G-A-C (OR = 6.10; 95% CI:2.28–16.35, p = 3.76E-4) and C-G-A-G-G-G-G-C-A (OR = 4.65; 95% CI:1.75–12.32; p = 2.21E-3, respectively).