Significant trends were observed in ccRCC cases that had germline minor alleles at VHL SNPs rs265318 (−2872 A>G), rs779805 (Ex1 +19 G>A), rs779812 (IVS1 −1184 G>A), rs1678607 (IVS2 +108 T>G), rs1642742 (Ex3 +473 G>A), rs1642739 (3835 bp 3′ST), and rs457414 (IRAK2 −3754 A>C). This evidence concerns the gene IRAK2 and nonpapillary renal cell carcinoma.