The association between inherited VHL polymorphisms and promoter hypermethylation in sporadic ccRCC case tumor DNA observed in the current study was similar to a previous report of 97 sporadic RCC cases [15] in which germline SNP rs779805 (Ex1 +19 A>G) was significantly associated with tumor-specific VHL promoter hypermethylation. This evidence concerns the gene VHL and neoplasm.