In the context of viral infection, re-localization of PABPC1 appears to be important for the shutoff effect since siRNA-mediated knockdown of PABPC1 diminishes the ability of SOX to target GFP mRNA for degradation, and since point mutations in SOX that ablate its effect on PABPC1 re-localization also abolish its downregulation of host mRNAs [19]. This evidence concerns the gene PABPC1 and viral infectious disease.