We found that ACs had HLA-A and -B molecules that are predicted to bind HBZ significantly more strongly than those in HAM/TSP patients (median difference 12%, p = 0.00005) [20] and that this effect was stronger in KIR2DL2+ individuals (median difference 25%, p = 0.00006) than in KIR2DL2- individuals (median difference 7%, p = 0.06); Figure 2a. The gene discussed is HLA-A; the disease is tropical spastic paraparesis.