Another report showed that a non-agonistic/antagonistic anti-CCR5 N-terminus specific mAb that is unable to block the binding of R5 HIV-1 gp120 to CCR5 interferes with R5 HIV-1 infection by induction of CCR5 dimerization rather than down-modulation of CCR5 [16]. Here, CCR5 is linked to HIV-1 infection.