Increased concentrations of Ca2+ into muscle cells may represent the critical link in the pathophysiology of CIPNM; proteolysis of myofibrillar structure proteins, mainly myosin thick filaments, is dependent on Ca2+ release from intracellular stores as the administration of dantrolene is able to block this response to sepsis in rat skeletal muscle [21]. This evidence concerns the gene MYH14 and Sepsis.