Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent enzyme, that belongs to the family of MMPs and contributes to the neuroinflammatory response in neuroinflammation and in neurodegenerative diseases such as amyotrophic lateral sclerosis [10], and Alzheimer's disease [11,12]. This evidence concerns the gene MMP9 and amyotrophic lateral sclerosis.