The expression of ABCC3 mRNA has been related to drug resistance [16] but to date only limited studies have been published studying polymorphisms in ABCC3. Only promoter SNPs and non-synonymous SNPs have been investigated as potentially functional variants [19], [20], but, to our knowledge, there are no studies showing association between these genetic ABCC3 variants and survival after treatment in cancer patients. The gene discussed is ABCC3; the disease is cancer.