Moreover, the loss-of-function mutation (plt1 mice) in the glycoprotein-N-acetylgalactosamine-3-galactosyltransferase (C1GalT1), essential for the synthesis of extended mucin-type O-glycans, produced underglycosylation of podocalyxin and glycoprotein Ib (GPIb) and caused thrombocytopenia and kidney disease, suggesting a contribution of the abnormally glycosylated Podxl to this pathology [15]. Here, PODXL is linked to Thrombocytopenia.