One possibility could be that Pumilio is involved in the regulation of ion channels as in Drosophila, where Pum regulates the voltage-gated sodium channel, para. Our gene expression analysis not only identified differential expression of genes in Pum2XE772 mice suggested to be regulated by Pumilio [9], [10], [39], but also genes known to be involved in seizures and/or epilepsy (Hspbap1, Stat9, Bax, Mapk14, Nav1.2, Nav1.6). This evidence concerns the gene HSPBAP1 and epilepsy.