Interestingly, the H2O2-mediated p-Akt response was similar between the two groups (a mean cell subpopulation of 58% for Group l and 52% for Group ll, Table 3), suggesting that an alternative phosphatase such as the H2O2–sensitive PTEN [41] is not differentially regulated in CLL and healthy B cells. The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.