PTEN and B-cell chronic lymphocytic leukemia: Interestingly, the H2O2-mediated p-Akt response was similar between the two groups (a mean cell subpopulation of 58% for Group l and 52% for Group ll, Table 3), suggesting that an alternative phosphatase such as the H2O2–sensitive PTEN [41] is not differentially regulated in CLL and healthy B cells.