Epigenetic agents can also induce (re)expression of a number of silenced genes encoding other immunoactive molecules, such as co-stimulatory molecules, adhesive ICAM-1 (CD54), NKG2D receptor and tumour-associated antigens (Tomasi et al, 2006; Fonsatti et al, 2007; Sers et al, 2009). Here, ICAM1 is linked to neoplasm.