COL18A1 and melanoma: A Matrigel invasion assay also demonstrated that endostatin significantly reduced invasion of the melanoma cells in a dose-dependent manner: 77.0±12.7% (P<0.05), 48.8±9.5% (P<0.01) and 39.8±10.2% (P<0.001) compared with the control (100±18.6%) in the presence of 5, 20 and 40 μg ml−1 endostatin, respectively (Figure 5B).