However, when screening patients with advanced immunodeficiency, the combined sensitivity of Determine TB-LAM test strips and smear microscopy combined (either test positive) did not differ significantly from that of the Xpert MTB/RIF assay for patients with CD4 cell counts less than 50 cells per μL or less than 100 cells per μL (figure 3, table 2). This evidence concerns the gene CD4 and immunodeficiency disease.