Among 115 patients with CD4 counts less than 100 cells per μL, the sensitivities were 62·5% (95% CI 40·6–81·2) for Determine TB-LAM and smear microscopy combined and 79·2% (57·8–92·9) for Xpert MTB/RIF with two samples (p=0·34). This evidence concerns the gene CD4 and tuberculosis.