To determine whether NRF2 also mediates upregulation of the antioxidant pathway in human FH-associated cancer we performed siRNA knockdown of NRF2 in UOK 262 cells, derived from lymph node metastases in an HLRCC patient with aggressive recurring kidney cancer (Yang et al., 2010). The gene discussed is NFE2L2; the disease is hereditary leiomyomatosis and renal cell cancer.