Using this modified asthma model with in vivo generated effector T cells, we demonstrate that although there was a reduction in recruitment of inflammatory cells and eosinophils in absence of IL-4Rα or STAT6, significant amounts of eosinophils were still present both in the BAL and also the lung tissue of STAT6xRAG2-/- and IL-4RαxRAG2-/- mice. Here, STAT6 is linked to asthma.