AKT1 and Familial prostate cancer: Magnolol inhibited cell proliferation through regulation of Cip1/p21 in human glioblastoma cells [52], induced apoptosis via inhibition of EGFR, PI3K/AKT signaling pathways in human prostate cancer cells [36] and inhibited MMP-9 expression through the transcription factor NF-kB in TNF-α- induced human urinary bladder cancer cells [53].