Strikingly, of the 39 up-regulated proteins identified in this experiment (Table 1, Figure 2, Additional file 3), UPR target genes, such as GRP78, GRP94, Hspb1, Calr, and Pdia3, were also increased in the acute phase of CVB3-infected myocarditis mouse heart tissues [20]. The gene discussed is PDIA3; the disease is myocarditis.