Because other proteins that are known to be involved with the generation of precursor metabolites and energy metabolism in mitochondria, such as ubiquinol-cytochrome c reductase complex core protein, succinate dehydrogenase, succinyl-CoA ligase beta chain, 2-oxoglutarate dehydrogenase E1 component and malate dehydrogenase, were also dysregulated in the CVB-infected myocarditis mouse heart tissues [11], the impaired functions of mitochondria in both murine models of myocarditis may be an underlying common pathogenic mechanism of myocarditis. This evidence concerns the gene PHGDH and myocarditis.