PPARA and metabolic dysfunction-associated steatohepatitis: The expression of peroxisome proliferator-activated receptor-α (PPAR-α), a transcription factor responsible for the activation of fat metabolism genes, was significantly decreased in the livers of NASH animals as compared to values observed in the control group (33% of control, P < 0.05), but was not affected significantly by any treatment in our study when compared to the NASH group as shown by the representative western blots (Figure 6(b)).