Viruses like coxsackievirus B3 (CVB3) are often detected in patient myocardial biopsies [3, 6], and antiviral treatments such as interferon (IFN)-β reduce inflammation and HF in animal models and patients [7, 8], implying that viral infections are an important cause of myocarditis cases that lead to HF. Here, IFNB1 is linked to myocarditis.